Bupropion alters the electrical activity of neurons in the brain. It was originally approved for use as an antidepressant and marketed under the name Wellbutrin. It has since been approved as an aid for smoking cessation and marketed as Zyban.

Fluoxetine belongs to a class of antidepressant drugs known as selective serotonin reuptake inhibitors (SSRIs), and is used to treat mental depression, obsessive-compulsive disorder (OCD), bulimia nervosa, and premenstrual dysphoric disorder (PMDD).

Fluvoxamine belongs to a class of antidepressant drugs known as SSRIs.